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Additional administration of epinephrine, often in the form of an autoinjector (Epi-pen), is required by people with such hypersensitivities.
H-antihistamines can be administered topically (through the skin, nose, or eyes) or systemically, based on the nature of the allergic condition.
These receptors both receive histamine as a messenger, but the meaning conveyed is different.
Understanding the mechanism for opioid-induced nausea will aid in the selection of appropriate agents.
Constipation is considered an expected side effect with chronic opioid use.
Both ketotifen and its metabolites appear to be largely excreted in the urine, with fecal elimination found only after the first 24 hours.
Based on the above pharmacokinetic data, it is assumed that any ketotifen that is systemically absorbed after ophthalmic application would be extensively metabolized and eliminated via the urine.